He graduated from the School of Medicine at Birmingham University and he completed his clinical training in Nottingham University Hospitals. For a number of years, he was a Primary Care Physician in Hampshire, during which he developed his special interest in Allergy Medicine. He further developed this interest during an educational visit to USA Allergy Centres in 1988 and in 1992 he acquired the Diploma in Allergy from the Cardiothoracic Institute, University of London. He was appointed Consultant in Allergy Medicine at University College London Hospitals in 1995.
Dr Radcliffe accepts referrals for the investigation and management of a wide range of conditions in which allergy might play a part including anaphylaxis, asthma, hay fever, allergic rhinitis, allergic conjunctivitis, food allergy, food intolerance, oral allergy, natural rubber latex allergy, drug and anaesthetic allergy, and bee or wasp venom allergy. He has a special interest in the investigation and management of recurrent hives (urticaria).
Amongst cases referred to him for an allergy assessment he is able to provide an opinion in almost every case. However, because of the need to rationalise expensive resources, for example when specialised drug and anaesthetic allergy testing is indicated, and also in cases of suspected skin contact allergy, Dr Radcliffe may decide to refer certain cases to one of his consultant colleagues. Similarly, he occasionally needs to make an onward referral in cases (for example treatment-resistant hay fever) in which he considers immunotherapy (desensitisation) treatment to be indicated.
To aid the investigation of complex food allergy he uses an emerging molecular diagnostic test that can simultaneously identify antibodies to 112 allergenic protein components from 51 different allergen sources. The test utilises a miniaturised microchip method that requires only a single 30 microlitre sample of blood serum. Even a pin-prick sample of blood is sufficient to undertake this test, the accuracy and efficiency of which improves on earlier methods such as skin prick testing or the RAST blood test.
In cases of suspected food intolerance, a condition for which scientifically validated tests have yet to be developed, he collaborates with highly qualified registered dietitians who specialise in food allergy and food intolerance. Whenever possible, the aim is to re-establish a healthy and compatible diet, an individualised approach that can sometimes transform lives.
He is a Scientific Advisory Board Member of Allergy UK and the Anaphylaxis Campaign.